• Position Overview

Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as Senior Director or Vice President, Preclinical Pharmacology & Toxicology. This foundational leadership role offers the opportunity to further establish and lead the Preclinical Pharmacology, Pharmacometrics, and Toxicology function, driving research programs from lead optimization through IND submission.

The SD/VP will be responsible for integrating nonclinical pharmacology, toxicology, and pharmacokinetics into the company’s R&D strategy, ensuring alignment with regulatory and scientific standards. This strategic leadership role guides non-clinical assessments from late research development through IND/CTA submissions and will have a significant and lasting impact on the company’s scientific direction and future success.

Key Responsibilities

• Strategic Program Leadership: Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategy across the portfolio. Drive the strategic vision for advancing programs from late-stage discovery through IND/CTA submission, ensuring alignment with corporate objectives and competitive positioning. Anticipate regulatory and scientific challenges, and proactively develop risk mitigation strategies to accelerate program timelines.

• Preclinical Study Oversight: Design, manage, and interpret pharmacology, PK/PD, and toxicology studies (GLP/non-GLP) to support program advancement. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages.

• Cross-Functional Integration: Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans.

• Scientific Excellence & Team Development: Mentor and develop internal team members, building organizational capabilities in disease- and target-relevant efficacy studies, PK/PD/biomarker strategies, and translational approaches across cardiovascular/metabolic and oncology therapeutic areas.

Required Qualifications

• PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline

• 10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical pharmacology, toxicology, and/or DMPK

• Demonstrated ability as program lead to advance programs from lead optimization to IND with complex biologics, such as antibodies, and/or antibody conjugates (ADCs, AOCs)

• Deep understanding of in vivo pharmacology and toxicology.

• Solid working knowledge in bioanalysis, PK/PD, and DMPK. Relevant experience with both biologics and small molecules is a strong plus.

• Experience delivering high-quality preclinical/nonclinical data packages for drug candidate selection and IND-enabling studies.

• Experience with cardiovascular/metabolic therapeutic area or oncology preferred.

Skills & Competencies

• Strong strategic thinking and scientific judgment with excellent problem-solving capabilities

• Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences

• Strong interpersonal skills with the ability to motivate, influence, and lead cross-functional teams in a matrixed environment

• Demonstrated ability to work collaboratively and influence at all levels of the organization

• Independent, self-motivated leader with the ability to work in a fast-paced, team-based drug discovery and development environment

About Salubris Biotherapeutics

Salubris Biotherapeutics, Inc. (or SalubrisBio) is a clinical-stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody-drug-conjugate and antibody-fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation. We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits. SalubrisBio is an equal opportunity employer committed to diversity and inclusion in the workplace.